Publications

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. Leptin potentiates astrogenesis in the developing hypothalamus. Molecular Metabolism, 2015. in press.

Valdearcos M, Xu AW, Koliwad SK. Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol, 2015. 77:131-60.

Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Reports, 2015. 10(1):62-74.

Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy, 2015. 11(1):145-54.

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Reports, 2014. 9(6):2124-38.

Olofsson LE, Unger EK, Cheung CC, Xu AW. Modulation of AgRP neuronal function by Socs3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A. 2013. 110(8):E697-706.

Newton AJ, Hess S, Paeger L, Vogt MC, Nillni EA, Bruning JC, Kloppenburg P, Xu AW. AgRP innervations onto POMC neurons increases with age and is accelerated with chronic high fat feeding in male mice.Endocrinology, 2013. 154(1): 172-183.

Warne JP, Xu AW. Metabolic Transceivers: In-tune with the Central Melanocortin System. Trends in Endocrinol Metab, 2013. 24(2): 68-75.

Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron, 2012. 75(3): 425-436.

Dietrich MO, Antunes C, Geliang G, Liu, Z-W, Borok E, Nie Y, Xu AW, Souza DO, Gao, Q, Diano, S,Gao, X-B, Horvath, TL. Agrp neurons mediate Sirt1’s action on the melanocortin system and energy balance: Roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci. 2010. 30: 11815-11825.

Reed AS, Unger EK, Olofsson LE, Piper ML, Myers Jr. MG, Xu AW. Functional role of Socs3 up-regulation in hypothalamic leptin resistance and long term energy homeostasis. Diabetes, 2010. 59: 894-906.

Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu AW, Bass J, Wang X. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol. 2010. 339: 38-50.

Unger EK, Piper ML, Olofsson LE, Xu AW. Functional role of c-Jun-N-terminal kinase in feeding regulation.Endocrinology, 2010. 151: 671-682.

Pierce AA, Xu AW. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010. 30: 723-730.

Olofsson LE, Pierce AA, Xu AW. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A. 2009. 106:15932-37.

Piper ML, Unger EK, Myers MG Jr., Xu AW. Specific physiologic roles for Stat3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008, 22(3): 751-9.