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JOURNAL CLUB

Control of energy homeostasis

We are a journal club with a focus on understanding the regulation of energy and glucose homeostasis. One person presents per meeting, in an open discussion format. Presentations are held every Monday at 5:00, in HSW 1128. For information or suggestions, contact Allison Xu.

The Xu and Vaisse labs also share a joint lab meeting every Thursday at 9:30 in HSW 1057.

Up-coming Schedule:

DATE PRESENTER PAPER
11/16/09 James Warne Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons + supplemental data
11/23/09 Ivan Rudenko TBA
11/30/09 Andrew Pierce TBA

Past presentations

DATE PRESENTER PAPER
11/02/09 Ivy Aslan Modulation of Blood Pressure by Central Melanocortinergic Pathways
10/26/09 Jacqueline Siljee Adult Type 3 Adenylyl Cyclase­Deficient Mice Are Obese
10/19/09 Jen Wade Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
10/05/09 Inma Valle Asencio Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues
09/21/09 Hélène Favre Inactivation of the Fto gene protects from obesity
09/14/09 Melissa Meucci FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
08/31/09 Baran Ersoy White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models
08/24/09 Louise Olofsson Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation
08/17/09 Clement Cheung Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding
08/10/09 Shi-Bing Yang

Cold-activated Brown Adipose Tissue in Healthy Men

Identification and Importance of Brown Adipose Tissue in Adult Humans

08/03/09 Andrew Pierce High-Fat Diet Induces Apoptosis of Hypothalamic Neurons
07/27/09 Allison Xu Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver
07/20/09 Ivan Rudenko Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons
07/13/09 Jamila Newton Endo meeting review
06/22/09 James Warne ADA meeting review
06/15/09 Jacqueline Siljee Central Nervous System Imprinting of the G Protein Gsα and Its Role in Metabolic Regulation
06/01/09 Jamila Newton 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus
05/18/09 James Warne Leptin Targets in the Mouse Brain
05/11/09 Christian Vaisse Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors
05/04/09 Hélène Favre Loss of Hypothalamic Response to Leptin During Pregnancy Associated with Development of Melanocortin Resistance
04/27/09 Melissa Meucci MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
04/20/09 Woo-ping Ge Obesity induces functional astrocytic leptin receptors in hypothalamus
04/13/09 Florence Lee Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons
04/06/09 Inma Valle Asencio Differential Responses of Orexigenic Neuropeptides to Fasting in Offspring of Obese Mothers
03/23/09 Ivy Aslan Intestinal Gluconeogenesis Is a Key Factor for Early Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice
03/03/09 Shi-Bing Yang A Mathematical Model of Murine Metabolic Regulation by Leptin: Energy Balance and Defense of a Stable Body Weight
02/23/09 Baran Ersoy Requirement of Bardet-Biedl Syndrome Proteins for Leptin Receptor Signaling
02/09/09 Andrew Pierce Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance + supplement
02/02/09 Jacqueline Siljee Keystone meeting review
01/26/09 Clement Cheung Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity
01/12/09 Jen Wade Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila + Supplement
01/05/09 Jamila Newton Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats
12/15/08 James Warne PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response
12/08/08 Liz Unger A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance + Supplement
12/01/08 Andrew Pierce Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
11/24/08 Jacqueline Siljee b-Arrestin–Mediated Localization of Smoothened to the Primary Cilium + Supplemental data
11/17/08 Louise Olofsson Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin
10/27/08 Sandy Do Overexpression of CART in the PVN Increases Food Intake and Weight Gain in Rats
11/03/08 Melissa Meucci Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
10/20/08 Hélène Favre Evidence for Constitutive Neural Cell Proliferation in the Adult Murine Hypothalamus
10/13/08 Woo-Ping Ge A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping
10/06/08 Allison Xu Hypothalamic IKKb/NF-kB and ER Stress Link Overnutrition to Energy Imbalance and Obesity + Supplemental
09/29/08 Inma Valle Asencio Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight
09/22/08 Shi-Bing Yang UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
09/15/08 Florence Lee Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
09/08/08 Baran Ersoy New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure + Supplement
08/25/08 Jamila Newton Imaging structure and function in the CNS (Cold Spring Harbor)
08/18/08 Sayali Ranadive Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
08/11/08 Jen Wade Starvation after AgRP neuron ablation is independent of melanocortin signaling
08/04/08 Chrisitan Vaisse Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
07/28/08 James Warne Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production + Supplementary Information
07/21/08 Liz Unger Regulation of AgRP mRNA transcription and peptide secretion by acute and chronic inflammation
07/14/08 Louise Olofsson Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
07/07/08 Clement Cheung Agouti-Related Peptide and MC3/4 Receptor Agonists Both Inhibit Excitatory Hypothalamic Ventromedial Nucleus Neurons
06/30/08 Andrew Pierce Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
06/23/08 Various presenters ADA / Endo meeting summaries
05/19/08 Inma Valle Asencio TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice
05/12/08 Sandy Do Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
05/05/08 Florence Lee Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
04/29/08 Melissa Meucci Leptin promotes adult hippocampal neurogenesis in vivo and in vitro
04/22/08 Baran Ersoy Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity
Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis
04/15/08 Jacqueline Siljee Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-Coupled Receptors
04/08/08 Jamila Newton Serotonin 5-HT2C Receptor Agonist Promotes Hypophagia via Downstream Activation of Melanocortin 4 Receptors
04/01/08 Andrew Pierce Obesity and Hypertriglyceridemia Produce Cognitive Impairment
03/25/08 Allison Xu Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice
03/17/08 Ali Reed PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans + Supplementary information + Background materials
03/11/08 Christian Vaisse Disruption of the RIIβ subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice
03/04/08 Jen Wade The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
Background material: Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players
02/28/08 Christian Vaisse, Allison Xu et al. Keystone meeting review
02/13/08 James Warne Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation + Supplemental Data
02/05/08 Liz Unger The central melanocortin system directly controls peripheral lipid metabolism + Supplimentary Material
01/29/08 Inma Valle Asencio Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes
01/14/08 Sandy Do Tumor-induced anorexia and weight loss are mediated by the TGF- beta superfamily cytokine MIC-1
01/07/08 Melissa Meucci Developmental Switch in Neuropeptide Y and Melanocortin Effects in the Paraventricular Nucleus of the Hypothalamus
12/11/07 Baran Ersoy Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity
12/17/07 Jacqueline Siljee Melanocortin-4 Receptor Activation Stimulates Hypothalamic Brain-Derived Neurotrophic Factor Release to Regulate Food Intake, Body Temperature and Cardiovascular Function
11/19/07 Jamila Newton SfN meeting review - Topics on neuroscience imaging
11/13/07 Andrew Pierce SfN meeting review - Topics on neuroendocrine regulation of energy balance
10/29/07 Jamila Newton Endocrine Regulation of Energy Metabolism by the Skeleton
10/01/07 Christian Vaisse Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease + supplemental data
09/17/07 Sayali Ranadive Hyperphagia and Early Onset Obesity due to a Novel Homozygous Missense Mutation in Prohormone Convertase 1/3
08/27/07 Jennifer Wade Creation of a genetic model of obesity in a teleost
08/13/07 Andrew Pierce TLR4 links innate immunity and fatty acid-induced insulin resistance
07/23/07 Ali Reed Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
07/09/07 Allison Xu Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
06/25/07 Inma Valle Asencio Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
06/11/07 Liz Unger Hypothalamic resistin induces hepatic insulin resistance
05/29/07 Baran Ersoy Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small molecule hypophagic agents
05/07/07 Gabe Loeb A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
03/19/07 Jacqueline Siljee A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2
03/26/07 Melissa Meucci Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
02/12/07 Andrew Pierce Altered Expression of SOCS3 in the Hypothalamic Arcuate Nucleus during Seasonal Body Mass Changes in the Field Vole, Microtus agrestis
01/22/07 Sayali Ranadive Role of the Central Melanocortin Circuitry in Adaptive Thermogenesis of Brown Adipose Tissue
01/08/07 Hélène Favre A brain-specific microRNA regulates dendritic spine development
12/11/06 Allison Xu Modulation of neuropeptide Y expression in adult mice does not affect feeding
10/30/06 Noelle Huskey miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation
09/24/06 Andrew Pierce Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
08/28/06 Christian Vaisse Serotonin reciprocally regulates melanocortin neurons to modulate food intake
08/07/06 Baran Ersoy Vaccination against weight gain
07/24/06 Melissa Meucci Overfeeding in identical twins: 5-year postoverfeeding results
07/10/06 Simone Tchu Hypothalamic mTOR signaling regulates food intake
06/05/06 Gabe Loeb Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
05/22/06 Hélène Favre Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
05/08/06 Merisa Piper Reactive oxygen species have a causal role in multiple forms of insulin resistance
04/10/06 Noelle Huskey Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus
03/27/06 Mehdi Skhiri Ghrelin controls hippocampal spine synapse density and memory performance

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